NMR spectroscopy is an incredibly powerful technique for the characterisation and analysis of many chemical compounds. Unlike many other analytical techniques, it is straight-forward to distinguish subtle differences in chemical structures, even distinguishing regioisomers, which differ only by the substitution patterns about an aromatic ring.

Regioisomerisation is common in pharmaceutical compounds, and in this application note we use the X-Pulse Broadband Benchtop NMR Spectrometer, readily distinguish paracetamol and its regioisomers, using one- and two-dimensional proton and carbon- 13 spectroscopy.

By downloading this application note you will learn

• What regioisomers are…
• How to distinguish regioisomers by NMR spectroscopy
• The different information that can be obtained by NMR spectroscopy

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