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Spin Locking: Total Correlation Spectroscopy (TOCSY)

Total correlation spectroscopy TOCSY, is a homonuclear 2D experiment similar to COSY (see application note 7) in which the J-coupling between two hydrogen nuclei manifests as a cross peak in the spectrum. Unlike COSY, however, the detection of the coupled spins is not limited to nearest neighbours. The TOCSY experiment exploits the isotropic mixing condition during spin locking to produce cross peaks between all hydrogen nuclei that form part of an unbroken chain of coupled spins.

Application Note: Spin Locking: Total Correlation Spectroscopy (TOCSY)

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