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2D NMR experiments at 60 MHz: COSY-90 and COSY-45

In December 2016 it was widely reported† that students from Sydney Grammar School reproduced the drug Daraprim®, also known as pyrimethamine. The students followed a reaction pathway to produce it, and the final product was analysed at the University of Sydney, School of Chemistry (200 MHz 1H NMR spectrum). This substance is used as an example to illustrate 60 MHz NMR spectrometer performance, and the difference between the two-dimensional (2D) experiments, COSY-90 and COSY-45.

Application Note: 2D NMR experiments at 60 MHz: COSY-90 and COSY-45

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